1,3-dipolar cycloaddition reaction of dibenzalaceton with non-stabilized azomethinylides: synthesis of new spirooxindolo(pyrrolizidines/ pyrrolidines)

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abstract

1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).

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1,3-Dipolar Cycloaddition Reaction of Dibenzalaceton with Non-stabilized Azomethinylides: Synthesis of New Spirooxindolo(pyrrolizidines/ pyrrolidines)

1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).

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1,3-Dipolar Cycloaddition Reaction of Dibenzalaceton with Non-stabilized Azomethinylides: Synthesis of New Spirooxindolo(pyrrolizidines/ pyrrolidines)

1,3-dipolar cycloaddition reaction of 1 mol or 2 mol of dibenzalaceton with 1 mol of non-stabilized azomethinylides generated in situ by decarboxylative condensation of isatin and proline or sarcosine give the novel new spiro-oxindolo(pyrrolizidines/ pyrrolidines) instead of bis-spirooxindolo( pyrrolizidines/ pyrrolidines).

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An efficient one-pot synthesis of C2-symmetric pyrrolidines and dispiro pyrrolidines/pyrrolizidines through 1,3-dipolar cycloaddition reaction

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a three-component 1,3-dipolar cycloaddition reaction of azomethine ylide for synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) derivatives

the development of multicomponent reactions (mcrs) designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. a comparative study of the synthesis of new bis-spiro-oxindolo(pyrrolizidines/pyrrolidines) ring systems by the cycloaddition of azomethine ylides generated by a decarboxylative route from sarc...

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Journal title:
international journal of bio-inorganic hybrid nanomaterials

جلد ۲، شماره ۳، صفحات ۴۵۷-۴۶۴

Keywords
[ 1 , 3 , ' d i p o l a r c y c l o a d d i t i o n ' , ' a z o m e t h i n y l i d e s ' , ' s p i r o ' , ' o x i n d o l o ( p y r r o l i z i d i n e s / p y r r o l i d i n e s ) ' , ' i s a t i n ' , ' p r o l i n e ' , ' s a r c o s i n e ' ]

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